Last updated on June 25th, 2025 at 12:41 pm
People often consider improving their cognitive health at one point or another.
However, it can be challenging to narrow down which supplements to choose to aid your mental performance. Why? Because there are many different types of supplements on the market.
Some supplements have proven results, while some don’t. That’s why we’ve looked at 3 of the most popular supplements for your consideration.
When you’re looking for a convenient shopping experience and a doctor-owned premier provider of nutritional and wellness products, look for Simply Nutrients. We aim to bring you a personalized way to get your brain health supplements.
Here are just some of the potential benefits of brain health supplements:
- Reduces stress levels
- Promotes healthy brain function
- Aids to improve cognitive function
- Supports brain health and brain cells
With a top-notch team and a wealth of knowledge, Simply Nutrients provides top-of-the-line supplements that can benefit your cognitive function. We also explore other ways you can promote a healthy brain.
Before we get into the specifics, let’s take a quick look at what brain health supplements usually contain.
What’s in Brain Health Supplements?
N-acetylcysteine (NAC) is one of the primary components in brain health supplements. This medicine is commonly utilized to help treat paracetamol overdose and has a well-established safety profile for a healthy brain — as seen in various studies [1].
Research (from the above studies) shows that the primary function of NAC as an antioxidant originates from its ability to increase the intracellular concentration of glutathione (GSH), an essential biothiol for cellular redox imbalance.
As mentioned in the Definitive Guide to N-Acetyl Cysteine, NAC has also been shown to regulate your brain’s glutamate levels, memory, and learning actions. In other words, it can increase your alertness.
With that in mind, let’s take a look at some of the best brain health supplements on the market.
1 – Thorne Research NAC + Pure Encapsulations Glycine
The first supplement we’ll visit is Thorne Research NAC (N-Acetylcysteine). One of most popular brands, Thorne Research NAC is a powerful antioxidant supplement that plays a key role in liver detoxification and immune support. As a precursor to glutathione—a critical antioxidant in the body—NAC helps protect the liver and kidneys from toxins while enhancing the body’s natural detox pathways. Its sulfur content aids in synthesizing glutathione, making it essential for maintaining cellular health and combating oxidative stress.
When taken with a supplement like Pure Encapsulations Glycine, NAC and glycine work together to support brain health by boosting glutathione levels and protecting neurons from oxidative stress. Glycine also acts as a calming neurotransmitter, which may support memory, mental clarity, and overall nervous system balance. Together, they promote detoxification and help maintain healthy brain function, especially under stress.
Pure Encapsulations is a manufacturer of hypoallergenic, research-based dietary supplements that deliver excellent results.
NAC and Glycine combine to support glutathione production, which is good for your immune system and detoxifying your body. The beneficial effects of glycine consist of potentially improving memory recall.
Glycine binds to N-Methyl-D-Aspartate (NMDA), a receptor that is an integral part of learning and memory. In short, they are brain-boosting supplements. [2]
Alongside the memory bonuses, NAC supports many bodily functions and may even contribute to relieving allergy symptoms (as mentioned in the Top 10 Natural Ways to Get Allergy Relief).
The supplement supports glutathione production, immune defense, and detoxification, not to mention the bonus of restoration and promotion of glutathione synthesis, which will demonstrate nothing but positive results.
Research also shows that this supplement may reduce oxidative stress associated with aging, tantalizingly paired with antioxidant defense promotion alongside your body’s natural detoxification process. [3] These results could promote brain function.
2 – N-Acetyl Cysteine by Ortho Molecular
Ortho Molecular N-Acetyl Cysteine, available in packs of 60 capsules, is an amino acid that not only boosts antioxidant function but is also a source of L-cysteine — an amino acid that can support your digestive health [4], help balance your blood sugar levels [5], and more.
Similarly, Ortho Molecular N-Acetyl Cysteine itself raises Glutathione levels [6], the vital antioxidant used in many metabolic processes within your body. Glutathione is also essential in maintaining respiratory, hepatic, and immune system health.
This particular brain health supplement is commonly used to aid in getting past sinus and airway congestion, supporting antioxidant and cellular detoxification pathways throughout your body.
This NAC, combined with its ability to dissolve mucus, might help relieve allergy symptoms.
Some other notable points are that Ortho Molecular N-Acetyl Cysteine:
- Improves glutathione status
- Supports healthy respiratory function
- Supports cellular antioxidant activity
- Includes 500 mg of this versatile amino acid per capsule
- Supports detoxification of environmental toxins and pollutants
Ortho Molecular N-Acetyl Cysteine supports antioxidant and cellular detoxification pathways in your body, with 60 capsules to make your experience last.
3 – Integrative Therapeutics NAC
Integrative Therapeutics NAC is a supplement known for its ability to help replenish intracellular glutathione – one of the body’s most important antioxidants. Glutathione plays a critical role in protecting cells from oxidative stress and supporting overall cellular health. By boosting these natural defenses, Integrative Therapeutics NAC can help promote a healthy response to everyday toxins and environmental stressors.
Clean, Simple Ingredients: Each capsule of Integrative Therapeutics NAC delivers 600 mg of N-Acetyl L-Cysteine. The formula is clean and simple, containing only a few other ingredients: gelatin (capsule), cellulose, and calcium laurate. It’s also free from gluten, dairy, soy, wheat, corn, artificial colors, flavors, and preservatives—making it a great option for those with dietary sensitivities.
How to Use Integrative Therapeutics NAC: Integrative Therapeutics NAC is easy to incorporate into your daily wellness routine. The recommended use is just one capsule per day, or as advised by your healthcare provider. Whether you’re looking to support detoxification or enhance your antioxidant defenses, Integrative Therapeutics NAC offers a targeted way to give your body the support it needs. Research shows that NAC has many positive effects, including eliminating free radicals and reducing oxidative stress. [7]
Recommended use is to take 1 capsule daily or as recommended by a healthcare professional. As with many NAC products, these supplements can also support normal levels of mucus in the sinus and respiratory system for healthy individuals.
Why Brain Health is Important
Now that we’ve explored some specific supplements, we should investigate why brain health is important.
As you undoubtedly know, your brain is the epicenter of your entire being and controls your bodily functions.
Maintaining a healthy brain is a crucial part of being able to think, perform daily tasks, and even rest, so you’ll want to ensure that you’re treating it with the respect it deserves.
You will want to keep your body physically healthy to support brain health and even prevent cognitive decline.
Some of the ways that you can potentially do this are:
- Exercising regularly
- Cutting out smoking
- Maintaining a balanced diet
- Staying socially active
- Getting a good amount of sleep
- Reducing or eliminating drinking alcohol
Ultimately, these methods can’t guarantee results, but in the past, doctors have stated that they can really make a difference. [8]
If you want to look at how Simply Nutrients can benefit you, then be sure to visit our website.
REFERENCES:
[2] https://pubmed.ncbi.nlm.nih.gov/10587285/
[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9261343/
[4] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017824/
[5] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3568688/
[6] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4540061/
[7] https://www.arborassays.com/glutathione-mediator-of-oxidative-stress/
[8] https://myhometouch.com/articles/why-is-brain-health-important
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