Collagen Peptides and Other Natural Alternatives to Peptide Therapy

Peptide therapy has become very common today. Many people are interested in using peptide therapy for muscle growth, anti-aging, weight loss, wound healing, joint pain reduction, skin health, and other benefits. However, there are some potential drawbacks to synthetic peptide therapy, including the high cost and possible side effects, which can turn people away. 

Fortunately, there are alternatives to synthetic peptide therapy that may have benefits, such as collagen peptides, herbs, antioxidants, and lifestyle changes. This article provides an overview of natural alternatives to peptide therapy, with a listing of specific supplements that may help reach your goals. 

What is Peptide Therapy?

With all the buzz around peptides lately, you may have asked, “What is peptide therapy?”. And to understand this, it’s first helpful to understand peptides in general. 

Peptides are groups of amino acids, which are the building blocks of protein. The body naturally produces thousands of different peptides, which are used for many different processes and functions, including immunity, hormonal regulation, metabolism, brain function, and much more. 

So, while the body does produce peptides naturally, peptide therapy most often refers to the use of synthetic peptides. These synthetic peptides are formulated to target specific processes. Peptide therapy can deliver peptides through various routes, such as:

  • Injection
    • Intravenous
    • Intramuscular
    • Subcutaneous (under the skin)
  • Oral
  • Nasal
  • Topical

And while synthetic peptides have been shown to be beneficial, they also carry a higher risk of side effects. In addition, peptide therapy is also often quite expensive. 

Natural Alternatives to Peptide Therapy

If you still want to experience the benefits of peptides but are concerned about the safety and/or cost of synthetic peptides, there are natural alternatives that may be beneficial. This includes collagen peptides, lifestyle modifications, and certain natural herbs and supplements. 

Collagen peptides are naturally occurring protein sources from animals, such as cows, pigs, chicken, and fish. Collagen is found naturally in our bodies, where it makes up a key component of connective tissues, such as in the skin, bones, nails, and cartilage. 

The use of collagen peptides can stimulate collagen production, which may in turn lead to several benefits, such as:

  • Decreased fine lines and wrinkles
  • More hydrated, elastic, and healthier skin
  • Reduced joint pain
  • Improved mobility

Plus, collagen peptides are easy to use, come with little to no side effects, and are generally quite affordable. 

Other possible alternatives to peptide therapy are lifestyle modifications. While this may seem unclear at first, you have to consider the benefits most people are seeking from peptide therapy, such as:

  • Weight loss
  • Muscle growth
  • Wound healing
  • Anti-aging
  • Pain management

When you look at these desired benefits, lifestyle modifications can go a long way in achieving these outcomes. Particularly beneficial lifestyle strategies include:

  • Adequate sleep
  • Nutrient-rich diet
    • Balanced with protein, fat, and carbohydrates
    • Rich in vitamins, minerals, and antioxidants
  • Regular exercise
    • Especially a combination of aerobic exercise, strength training, and flexibility/mobility work
  • Stress management

All of these lifestyle strategies can help combat inflammation, balance stress hormones, improve metabolism, and provide numerous other effects that promote an overall healthier mind and body. 

With further regard to diet, there are many foods rich in collagen peptides that can provide benefits similar to synthetic peptides, such as those found in meat, fish, milk, lentils, soy, eggs, and wheat. 

Lastly, there are natural supplements that may be effective alternatives to synthetic peptide therapy, depending on your desired benefits. Examples include:

  • Magnesium: This essential mineral helps to reduce stress, promotes a healthy metabolism, supports hormonal health, and aids muscle recovery, among other benefits.
  • Berberine: This is a natural compound that may improve blood sugar regulation, insulin sensitivity, and fat metabolism, making it a natural weight loss option. It also has antioxidant and anti-inflammatory properties. 
  • Omega-3 Fatty Acids: These fatty acids make up a key component of cell membranes and may help reduce inflammation, improve brain function, reduce joint pain, and support heart health. 
  • Creatine: This natural compound can be stored in the muscles, where it is used as an energy source during high-intensity exercise, thus promoting muscle growth and strength. 

Dietary Supplements as Alternatives to Peptide Therapy

Simply Nutrients offers several supplements that may work as beneficial alternatives to synthetic peptide therapy, depending on your goals. Listed below are some top choices: 

  • OIAM Restore Collagen Peptides: OIAM Performance offers high-quality, proven supplements for athletic performance and overall wellness. Their Restore Collagen Peptides provides 15 g of collagen peptides from 3 unique forms, along with hyaluronic acid, vitamin C, and orthosilicic acid. This combination promotes collagen production and supports healthy joints, skin, hair, and nails. 
  • Metagenics Berberine GT: Metagenics provides a diverse line-up of nutritional supplements for overall health and vitality. Berberine GT contains 500 mg of berberine and 200 mg of green tea extract. Together, they support a healthy metabolism and weight loss, help balance cholesterol and blood sugar, and promote cardiovascular health. 
  • Metagenics Magnesium Glycinate: Another high-quality supplement from Metagenics is Magnesium Glycinate, which provides 100 mg of magnesium per serving in an easily digested, well-absorbed form. Magnesium supports your energy, sleep, muscle health, brain function, and much more.
  • True Grace Omega-3 Fish Oil: True Grace is a well-trusted brand you can count on for top-tier products. Their Omega-3 Fish Oil contains 1,500mg of omega-3s per serving, including 800 mg of EPA and 600 mg of DHA. These omega-3 fatty acids provide critical nutritional support for a healthy brain, immune system, heart, joints, and overall wellness. 

Overall, there are many ways to promote better health without resorting to synthetic peptide therapy. While this therapy can have benefits, many individuals will find success through initial alternative measures, such as lifestyle modifications and the use of collagen peptides, antioxidants, and other natural compounds. Always consult your doctor before changing your regimen or starting any new supplements. 

FAQs

What is peptide therapy used for?

Peptide therapy is used to target specific processes and/or functions in the body, such as hormonal regulation, muscle growth, immune support, weight loss, and wound healing/recovery. The exact peptides used depend on the desired benefits. Peptide therapy also improves skin elasticity by stimulating collagen and elastin production, which are essential proteins that maintain firm, youthful skin. These peptides signal skin cells to repair and regenerate, leading to smoother texture and reduced sagging over time.

What is peptide therapy for weight loss?

Peptide therapy for weight loss involves the use of specific peptides that influence metabolism, appetite, and other factors affecting weight management. It has been shown to provide benefits, although many individuals can experience similar benefits with lifestyle modifications, even if the results take a bit longer. 

How is peptide therapy administered?

Peptide therapy can be administered through multiple ways, such as through injections, oral capsules like collagen supplements, nasal sprays, or topical creams. 

Doctor

Medically reviewed by Dr. Jamy Antoine, D.C. — by Jack Cincotta — On May 16, 2025

Doctor

Jack Cincotta

Jack Cincotta is a board-certified holistic health practitioner through the American Association of Drugless Practitioners (AADP), and holds a Master of Science degree in Psychology. This combined background allows him to focus his holistic health practice on mental health issues, such as anxiety and depression, although he is well-versed in overall wellness optimization too. Jack is also a freelance writer for various health and wellness websites, in which he writes research-backed health and wellness articles to help others live a healthier, more balanced life.