DIM Supplement Benefits for Men and Women

DIM, or diindolylmethane, is a compound gaining popularity as one that could benefit your health in several ways. The benefits of DIM are highest when taken in dietary supplement form. This is because you would have to eat vast amounts of cruciferous vegetables like broccoli to achieve enough DIM equal to that in supplements. 

Keep reading to learn more about what DIM is, the benefits it holds for both men and women, and what DIM supplements you can try today to enhance your health. 

What is DIM?

The body produces DIM when you digest cruciferous vegetables like broccoli or Brussels sprouts. It is a bioactive indole, which shows promise for helping lower the risk of certain cancers such as breast and prostate cancer. In the human body, the highest amount of DIM is in the liver, with lower amounts in the kidney, lung, and heart. 

DIM Supplement Benefits

There are many potential DIM supplement benefits for your health, including various potential health benefits for women and men. 

Potential Health Benefits of Taking a DIM Supplement for Women

Taking a DIM supplement for women may support hormonal balance by promoting healthy estrogen metabolism, which can help reduce symptoms of PMS and menopause. Using a DIM supplement for women may also support clearer skin and reduce mood swings through its natural detoxifying effects. Additionally, a DIM supplement for women may aid in maintaining a healthy weight and support estrogen balance, as well as breast and reproductive health.

Potential Health Benefits of Taking a DIM Supplement for Men

Although most of the research on DIM shows the likely health benefits of a DIM supplement for women, this compound can also benefit men. By helping to reduce estrogen levels, a DIM supplement for men may help reduce the risk of erectile dysfunction, gynecomastia (enlarged breast tissue), and infertility, all of which are linked with high estrogen levels in men. Taking a DIM supplement for men may support better hormonal balance and overall well-being, contributing to a healthier, more youthful body composition.

DIM Supplement for Weight Loss

Studies show that DIM can enhance estrogen metabolism in patients with thyroid proliferative disease (TPD), offering promise as an antiestrogenic supplement that may help reduce the risk of developing TPD. 

Because of this anti-estrogen property, some early animal studies suggest that DIM could help address hormonal imbalances linked to weight gain, but further human studies are needed to confirm these effects. A 2017 study indicated that DIM significantly suppressed HFD-induced obesity, a condition associated with decreased fat tissue, and a 2023 human study revealed that individuals who took 75 mg of DIM daily for 30 days had a greater reduction in body fat compared to the placebo group, which may also help support testosterone levels and promote a healthier body composition.

DIM Supplements to Try

Since DIM is not a well-known compound like some others, you may not know where to find a trusted DIM supplement. Below are three trustworthy DIM supplements we suggest you try today. 

Nature’s Way DIM-Plus Estrogen Metabolism is a DIM supplement blend that contains a “Protectamins Vegetable Blend” created by Nature’s Way. This extra blend provides phytonutrients, a type of antioxidant, from extra cruciferous vegetables like spinach, broccoli, and cabbage. 

The DIM in this supplement helps support the increase of “favorable” estrogens (2-hydroxy-estrogen) while reducing the level of “less favorable” estrogens (16 hydroxyestrogen). This patented complex is free of gluten, salt, wheat, dairy, and artificial flavors or colors and is not made for children under 18 years of age. Just two capsules daily for women and two capsules twice daily for men can help balance estrogen levels to support reproductive and overall health. 

Douglas Labs DIM Enhanced is a microencapsulated form of DIM that also contains the antioxidant compounds curcumin, green tea, and wasabia. Research shows these compounds may help support healthy glucose metabolism and reduce chronic disease risk. 

This microencapsulated form of DIM by BioResponse is patented and highly absorbable with sustained release when compared to generic crystalline DIM supplements. Just one or two daily capsules of the DIM Enhanced supplement by Douglas Labs can help balance your estrogen levels today for overall health.

Allergy Research Group DIM Enhanced Delivery System features BioResponse DIM, which is a highly bioavailable form of diindolylmethane made from cruciferous vegetables like broccoli and cauliflower. Its unique proprietary delivery system ensures that the consumer receives stable and efficient absorption. 

The DIM Enhanced Delivery System by Allergy Research Group is free of common allergens like wheat, gluten, dairy, eggs, soy, fish, shellfish, peanuts, tree nuts, and yeast, making it ideal for anyone with food intolerances or allergies. Just two to four capsules of this supplement daily can help support healthy hormone metabolism.

A DIM supplement is one of many possible additions to your daily routine that could support a healthy lifestyle. Your healthcare provider can help you determine what vitamins and supplements may work best for you. Find more women’s health supplements and men’s health supplements on SimplyNutrients.com.

References:

  1. https://www.cancer.gov/publications/dictionaries/cancer-drug/def/diindolylmethane
  2. https://pmc.ncbi.nlm.nih.gov/articles/PMC3048776/
  3. https://www.healthline.com/nutrition/dim-supplement 
  4. https://pmc.ncbi.nlm.nih.gov/articles/PMC5059820/
  5. https://pmc.ncbi.nlm.nih.gov/articles/PMC3048776/
  6. https://pubmed.ncbi.nlm.nih.gov/28586165/#:~:text=3%2C3’%2DDiindolylmethane%20suppresses,adipocytes%20by%20targeting%20USP2%20activity
  7. https://pubmed.ncbi.nlm.nih.gov/36111381/
  8. https://www.nature.com/articles/s41598-020-69712-6#:~:text=Five%20hundred%20and%20sixty%2Dnine,to%20PE%20and%20ED%20groups.
  9. https://my.clevelandclinic.org/health/diseases/22363-high-estrogen
  10. https://pubmed.ncbi.nlm.nih.gov/32947952/
  11. https://pmc.ncbi.nlm.nih.gov/articles/PMC6857679/#:~:text=By%20interfering%20with%20the%20key,stress%20in%20horses%20and%20ponies.

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Medically reviewed by Dr. Jamy Antoine, D.C. — by Staci Gulbin — On June 2, 2025

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Staci Gulbin

Staci Gulbin has been a registered dietitian since 2010 and has treated hundreds of patients for nutrition-related issues ranging from weight management, diabetes, heart health, renal health, and bariatric surgery nutrition. She has been a freelance health writer since 2011 for sites including Shape.com, Health.com, and GoodRx.com, to name a few and has been a featured nutrition expert on websites like OprahMag.com. Through her work, Staci hopes to help people improve their relationship with food and their bodies. Staci has two cookbooks published on Amazon.com ("The High Protein Bariatric Cookbook" and "The Healthy Bariatric Smoothies Recipe Book"), a healthy living podcast No Sugar Coats found on Spotify, Apple Podcasts, and iHeart podcasts, as well as a blog at www.lighttracknutrition.com.

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