Last updated on June 25th, 2025 at 12:43 pm
It’s more than likely you know about Ozempic from its current headlines in the weight management world. But you may not know what Ozempic does to your brain. Although there are no severe adverse brain health effects of Ozempic, some mild brain fog has been mentioned. (Source 1)
Keep reading to learn more about Ozempic, what taking it may do to your brain health, how to get rid of brain fog, and what natural supplements may be able to provide similar weight management benefits.
What is Ozempic?
Ozempic is a type of semaglutide, or GLP-1 receptor agonist (GLP-1RA) whose main role is to help treat those with type 2 diabetes (T2DM). (2) Recent off-label use of Ozempic has been to aid in weight loss for those with obesity. (3) Ozempic helps with weight loss by activating GLP-1 receptors mainly located in the gut, pancreas, and brain which in turn helps reduce appetite.
Ozempic has also been approved for helping to lower your risk of heart disease events such as heart attack or stroke in adults with T2DM and a history of heart disease.
Ozempic and Brain Health
So, now that you know a bit about what Ozempic is, let’s talk about what Ozempic does to your brain. On the bright side, some research shows that semaglutide medicines like Ozempic can improve symptoms of certain mental health issues like anxiety and depression by reducing inflammation in the body. (4) Also, alcohol- and other substance-use disorders may also benefit from the effects of GLP-1RA like Ozempic. Limited research done on this topic shows that GLP-1RAs may help control the dopamine and opioid pathways that are not working properly in the brains of those with addiction. (5)
However, some people who have taken Ozempic report changes in personality for the worse such as increased anxiety and worsened mood. (6) Some also report that Ozempic has caused them brain fog, or a lack of focus in daily life. (7, 8) This finding has not been studied formally, but experts suggest that it may be a result of dehydration, lack of certain nutrients, or low blood sugar that may occur in some who take Ozempic.
How to Get Rid of Brain Fog
How to get rid of brain fog through nutrition involves focusing on eating whole foods rich in omega-3 fatty acids, antioxidants, and B vitamins—such as fatty fish, leafy greens, and berries. Stay hydrated and limit processed sugars and refined carbs, which can spike blood sugar and worsen mental clarity. Incorporating probiotic-rich foods like yogurt or fermented vegetables can also support gut health, which is closely linked to brain function.
Natural Weight Management Support Supplements
If you’re taking Ozempic and are having brain fog or other brain health symptoms, you can try one of the supplements below instead to help support weight loss without brain fog.
Codeage GLP-1 Probiotic+ is a probiotic product with 500 million active fluorescent units (AFUs) per dose. It includes strains like Akkermansia muciniphila that research shows may help improve metabolic health. (9) This vegan, non-GMO supplement is also free of soy, gluten, and dairy, and contains the prebiotic chicory inulin to help nourish the probiotics it contains. Just one capsule daily of this supplement, made in the USA in a cGMP-certified facility for your safety, can support optimal gut and metabolic health.
Pure Encapsulations PureLean Pure Pack is a comprehensive multivitamin product that contains unique compounds like Chromium 454® and taurine to help improve glucose metabolism, in turn supporting weight management. These convenient supplement packs ensure you don’t forget to take any of your daily essentials so you can reap optimal benefits. This hypoallergenic dietary supplement also contains alpha lipoic acid as well as EPA and DHA with lemon for antioxidant support. These compounds help to reduce inflammation so you can enjoy a lower risk of heart disease.
Irwin Naturals Stored-Fat Belly Burner is a truly unique weight loss support supplement that contains the compound Sinetrol, which has been clinically studied for its ability to break down stored fat in the body. (10) Just three capsules daily twice a day can help you reduce body fat, while the addition of grapefruit, sweet orange, blood orange, lemon peel and tangerine along with Irwin’s BioPerine Complex, enhance absorption of key nutrients from the food you eat.
Natural Ways to Get Rid of Brain Fog
If you want to improve brain health without focusing on losing weight, then give the following products a try.
Metagenics Wellness Essentials Brain Health daily packs provide you with essential nutrients to support brain health in 30 convenient prepacked supplement doses per box. Each dose contains a multivitamin as well as a proprietary blend of 13 concentrated extracts and phytonutrients. In particular, this product contains magnesium L-threonate, which research shows can improve memory and cognition. (11) Not to mention that the antioxidant-rich omega-3 fatty acids found in the OmegaGenics Neuro 1000 compound in this supplement can help increase learning, memory, cognitive well-being, and blood flow in the brain. (12)
NutriDyn Brain Support is a dietary supplement focused solely on improving cognitive function. Ingredients like BcM-95 Curcugreen and green tea extract, which produce higher levels of curcuminoids, can help improve working memory and provide protection and preservation of cognitive function, respectively. (13, 14) Antioxidant compounds like resveratrol and Chinese Skullcap Extract can support brain health by working to neutralize the free radicals that may be detrimental to the brain.
Final Note on GLP-1
GLP-1 has the potential to help you lose weight and reduce your risk of heart disease. But just like other weight loss supplements, there are risks that may not have been studied enough yet. (15) That is why when taking any weight loss supplement or medicine, you should consult your healthcare provider first and stop taking it if you experience any adverse effects.
The safest way to lose weight long-term is to eat plenty of fiber-rich fruits and vegetables daily, drink plenty of water, eat enough lean protein with every meal, and move more each day, among other things. (16) Slow and steady weight loss will help you reach your health goals and maintain them for the long term while helping keep your brain healthy along the way. (17, 18) Simply Nutrients offers a wide range of weight management supplements to help you along the way.
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* These statements have not been evaluated by the Food and Drug Administration. The products mentioned are not intended to diagnose, treat, cure, or prevent any disease.
