Why is NAC Banned or Not?
The good news is that as of the writing of this article on June 13th, 2021 it’s not banned by the FDA but warning letters have been sent to multiple manufacturers that invoked the Drug Exclusion Provision in U.S. code Title 21 to ban the sale of n-acetylcysteine (NAC). The drug exclusion provision means is that if there was a prescription drug created for NAC which was done in 1963 according to the FDA and NAC was not marketed as a dietary supplement prior to that, the dietary supplement can be banned in favor of only using it as a drug.
It is very odd that both the prescription version and dietary supplement versions have been living in harmony for over 40 years but all of the sudden in the last year or so the FDA is trying to ban the dietary supplement version of NAC. I’ve done a considerable amount of reading and talking to experts on this and to date there is not a clear reason that has been presented for banning NAC as a dietary supplement.
The matter is far from settled, however, as Lawyers for the Council for Responsible Nutrition (CRN) has said this exclusion is “legally invalid”. Furthermore, the Natural Products Association (NPA) recently issued a statement advising manufacturers to continue making NAC products and for retailers to continue selling their NAC products on other websites besides Amazon. Only time will tell if N-Acetyl-Cysteine will be banned or not but for now it’s legal and available.
What is NAC – N Acetyl Cystiene Used For?
NAC has been used for over five decades in clinical medicine as a mucolytic agent (clearing up mucus), for respiratory infections, lung weakness and for lung diseases such as asthma, sinusitis, chronic obstructive airways disease (COPD), bronchiectasis, chronic bronchitis, cystic fibrosis and pulmonary fibrosis. You can do a search of pubmed Research has proven that NAC can be used alone, or in combination with antibiotics or other antimicrobial agents, to eradicate some chronic infections.
1. Helps With Detoxification to Reduce Kidney and Liver Damage
NAC is used frequently in hospital settings. For example when a patient comes in with an acetaminophen overdose the standard protocol is to use intravenous NAC to protect the liver and help the body excrete the toxins from the overdose. It does this by replenishing levels of glutathione which is one of the body’s most important antixoidants.
The liver stores glutathione and think of it like the sawdust that absorbs an oil or gas spill in the garage. It’s super handy and then it’s easily swept up and disposed of after it absorbs the oil or gas. In this case glutathione is absorbing the toxic aftershock of the acetaminophen overdose. If large doses of acetaminophen were taken the glutathione in the liver may run out and the body doesn’t have enough to detoxify the bad stuff the acetaminophen the body is producing.
NAC is a glutathione precursor meaning it helps the body replenish glutathione which helps the body restore its depleted levels. Don’t take my word for it as a double blind, placebo control study showed a 28% reduction in mortality when IV NAC was administered after an acetaminophen overdose.(6)
2. Helps To Avoid A Hangover
This certainly doesn’t mean you should try and test the limits of NAC’s ability to help avoid a hangover but there is some science behind this. Drinking alcohol draws down glutathione stores and taking NAC is one of the most effective ways to build glutathione back up so you may want to consider NAC for your nights out on the town.
3. Helps Relive Respiratory Symptoms
NAC is a natural mucus sledge hammer and by acting as an antioxidant NAC can reduce expectorant and loosen mucus in your airways which can reduce symptoms of respiratory conditions. N-Acetylcysteine replenishes glutathione levels in your lungs which helps to reduce inflammation in your lung tissue and bronchial tubes.
People with COPD have long recognized NAC as an effective way to improve COPD symptoms and lung decline as evidenced in a one year study. Participants in the study took 600mg of NAC twice and day and the result was significantly improved lung function in those with stable COPD. (7,8,9,10)
People affected by chronic bronchitis may also benefit from NAC. Bronchitis occurs when the mucous membranes in your lungs’ bronchial passageways become inflamed, swell and shut off airways to your lungs. NAC may help thin the mucus in your bronchial tubes. It will also boost glutathione levels which can decrease the severity and frequency of wheezing, respiratory attacks and coughing that are a part of bronchitis. (11,12)
In addition to relieving COPD and bronchitis, NAC may improve other lung and respiratory tract conditions like cystic fibrosis, asthma and pulmonary fibrosis. It may also relieve symptoms of nasal and sinus congestion due to allergies or infections. (13)
4. May Improve Addictive Behavior and Psychiatric Disorders
NAC is a powerful antioxidant that helps regulate glutamate which is the most important neurotransmitter in your brain. If you have too much glutamate along with too little glutathione (remember that NAC helps increase glutathione production) it can actually cause brain damage.
This combination of too much glutamate and too little glutathione may contribute to adverse mental health conditions. Some examples would be addictive behavior, schizophrenia, bipolar disorder and obsessive-compulsive disorder (OCD). (14,15,16,17)
An animal study found that NAC may minimize effects such as social withdrawal, apathy and reduced attention spans found in people suffering from schizophrenia.(18) NAC has also been used to decrease withdrawl symptoms in everything from cocaine addicts to marijuana and nicotine addicts. Preliminary studies show that it may decrease cravings. (19,20,21,22)
Does NAC Affect Sleep?
There’s good news around NAC and sleep. Experts have found that high levels of glutathione in the body may help you sleep better. In one study, it was found that those who had increased levels of glutathione were able to fall asleep easier at night and wake up refreshed in the morning. Moreover, it was found that the body is able to naturally produce more glutathione during sleep. N-Acetyl-Cysteine helps to replenish intracellular glutathione therefore it may help support both a longer and more restful sleep.
For those with sleep apnea there have been a few specific studies supporting NAC. From one of those studies(1) if you have obstructive sleep apnea syndrome (OSAS) taking oral NAC “appears to have therapeutic potential”. The study also proposed that “long term treatment with NAC in patients with OSAS may reduce their dependency on continuous positive airway pressure therapy otherwise known as CPAP machines. If you’ve ever been hooked up to a CPAP machine and I have if there were a way to get off of it I’d do pretty much anything.
When to Take NAC
Single amino acid supplements, like N-acetylcysteine, are best taken on an empty stomach. The absorption of amino acids can be affected by the foods you take them with and by other amino acids.
Is NAC Safe To Take Everyday
There have been multiple studies including (this one) showing the efficacy and safety of taking NAC over prolonged time periods so it appears from various studies that there is no known reason why NAC shouldn’t be taken over extended periods.
Your body can produce cysteine naturally therefore there isn’t a specific dosing recommendation and you should consult your healthcare practitioner for a personalized dosing schedule. As a supplement NAC is not especially well absorbed. For most manufacturers the daily supplement recommendation is anywhere from 600mg – 1800mg of NAC. (4)(5)
If you’re looking to get more NAC in your natural diet you can look to protein rich foods. Specificallly eggs, cheese, yogurt, chicken, turkey, ostrich, and legumes are good sources.
What are the side effects of NAC – N-Acetylcysteine?
Before taking any supplements please consult with your healthcare practitioner to make sure they are right for you and won’t cause any unsafe interactions. NAC has been around for over 50 years both in prescription drug form and as a dietary supplement and is generally considered safe.
NAC may slow blood clotting so people taking blood thinning medications or with bleeding disorders should not take NAC.(2) NAC in higher amounts can cause diarrhea, constipation, nausea or vomiting and if you experience any of these symptoms please stop taking NAC and consult your healthcare practitioner.
NAC has an odor in powder form that can make it hard to consume so its recommended to be consumed in capsule form. NAC should not be inhaled as people have experienced symptoms such as swelling the moutch, chest tightness, runny nose and drowsiness. (3)
What is a Good Brand of NAC?
A good brand is one that is independently tested, whose manufacturing processes are certified by a reputable organization and who regularly tests and certifies their raw ingredients against any impurities. It’s a plus for them to make all their products with non-gmo and hypoallergenic ingredients. From the last 15 years in business we trust the following brands that make a NAC product:
- Pure Encapsulations (NAC 600mg | NAC 900mg)
- Douglas Labs (NAC 500mg | 750mg)
- Thorne (NAC 500mg)
- Vital Nutrients (NAC 600mg)
- Nutridyn (NAC 600mg)
- Integrative Therapeutics
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- Anti-oxidant treatment in obstructive sleep apnoea syndrome