Best Digestive Enzymes With Probiotics: A Must-Have Guide

Last updated on January 25th, 2024 at 09:34 am

​When embarking on a quest for digestive well-being, one dynamic duo takes center stage in the world of nutritional support: digestive enzymes with probiotics. 

As our awareness of the intricate workings of the intestines deepens, we’ve become more attuned to the pivotal role played by digestive enzymes

These little powerhouses diligently break down proteins, fats, and carbohydrates to ensure the nutrients from your favorite meals are effectively absorbed.

In this guide, we’ll navigate through the intricate realm of digestive enzymes, shedding light on the indispensable role they play in promoting digestive harmony

We’ll also explore their symbiotic relationship with probiotics, uncovering how the pair aid digestion and encourage a thriving ecosystem of beneficial bacteria in the gut.  

What are Digestive Enzymes?

Digestive enzymes are specialized proteins that play a crucial role in the process of breaking down complex food components into simpler, absorbable forms

They are produced naturally in various parts of the GI tract, including the mouth, stomach, pancreas, and small intestine.

Each type of digestive enzyme targets a specific nutrient, facilitating its conversion into smaller molecules that the body can readily utilize.

Here are the primary types of digestive enzymes and their respective functions:

Digestive EnzymeLocationFunction
ProteaseStomachBreaks down proteins into small peptides and amino acids

Saliva and in pancreatic juices
Breaks carbohydrates into simpler sugars
LipasePancreatic juices and the small intestineBreaks fats into fatty acids and glycerol

Digestive enzymes are essential for efficient digestion and nutrient absorption. They ensure that the vitamins and minerals from the food we consume are broken down into forms the body can use for energy, growth, and repair.

Factors such as age and certain health conditions can influence the natural production of digestive enzymes, making supplementation necessary to maintain optimal intestinal function.

How Do I Know if I Should Take Digestive Enzymes?

Healthy individuals produce the right amount of digestive enzymes that their bodies need. However, there are various signs that may indicate a potential benefit in taking digestive enzyme supplements:

  • Digestive discomfort: If you frequently experience bloating, gas, indigestion, or discomfort after meals, it may suggest your body isn’t effectively breaking down and absorbing nutrients.
  • Food intolerances: Individuals with specific intolerances, such as gluten intolerance, may find relief from digestive enzymes that target the breakdown of these substances.
  • Age-related decline: As you age, natural enzyme production tends to decline. If you’re noticing changes in your digestive function or nutrient absorption, supplementation may be beneficial.
  • Pancreatic issues: Conditions affecting the pancreas, such as chronic pancreatitis or pancreatic insufficiency, can lead to a decrease in enzyme production.
  • Poor diet: Eating low amounts of fruits and vegetables with a high amount of processed foods may negatively affect your digestive enzymes.
  • Skin issues: Skin problems, such as acne, eczema, or dermatitis, may sometimes be linked to digestive issues. Since the skin is an organ of elimination, poor digestion can contribute to skin imbalances.
  • Inflammatory bowel diseases: Individuals with conditions like Crohn’s disease or ulcerative colitis could cause a deficiency in digestive enzymes. 

Remember: Digestive enzymes may not be necessary for everyone, and it’s important to address lifestyle factors, dietary habits, and underlying health conditions. Discuss your symptoms with your doctor to determine the most suitable approach for your digestive well-being.

Digestive Enzymes vs. Probiotics

Digestive enzymes and probiotics are both key players in your gastrointestinal tract.

Like digestive enzymes, probiotics aid digestion. These tiny microbes that live in your gut contribute to intestinal processes and foster a balanced environment within it.

While digestive enzymes focus on breaking down specific nutrients into absorbable forms, probiotics maintain the delicate balance of the gut microbiome(1). These “good” bacteria don’t break down food themselves, but assist digestive enzymes with their work(2).

An imbalance of “good” and “bad” microbes in the gut, known as dysbiosis, can also have profound effects on digestive health. When harmful bacteria outnumber the beneficial ones, it can lead to issues like bloating, gas, cramps, and irregular bowel movements(3).  

The Synergy of Digestive Enzymes and Probiotics


(Image source: Unsplash)

Probiotics and digestive enzymes work together to promote optimal intestinal health.

Beneficial bacteria create an environment conducive to optimal absorption of the nutrients broken down by digestive enzymes. A healthier microbial balance enhances the efficiency of this critical process.

Both digestive enzymes and probiotics also reduce digestive discomfort

While enzymes help prevent undigested food particles from reaching the lower gastrointestinal tract to reduce the likelihood of bloating, probiotics balance the gut and minimize the risk of stomach aches by preventing the overgrowth of harmful bacteria.

While an adequate amount of digestive enzymes isn’t directly linked to immune function, efficient digestion supports overall health and indirectly influences the immune system

Probiotics actively support immune function by modulating the balance of immune cells in the gut and promoting a robust immune response(4).

The Benefits of Digestive Enzyme Supplements

Digestive enzyme supplements offer several potential health benefits, especially for individuals who may experience challenges with nutrient absorption.

Here are some key advantages associated with the use of these products:

Increased Nutrient Absorption

This is the primary function of digestive enzymes in your body. Supplements can enhance the breakdown of macronutrients like protein, carbohydrates, and fats, facilitating the optimal absorption of essential vitamins from the food you eat(5).

May Help Alleviate Inflammation

Digestive enzyme supplements have the potential to ease inflammation, particularly when it is linked to intestinal issues. By improving nutrient absorption, these products can reduce stress on the gut lining and promote overall gut health.

Chronic digestive conditions, like inflammatory bowel diseases, often involve inflammation in the gastrointestinal tract. Digestive enzymes may help alleviate symptoms associated with these conditions, potentially helping inflammation.

Management of Digestive Disorders

Supplementation with digestive enzymes plays a crucial role in managing various digestive disorders by addressing deficiencies in natural enzyme production and aiding in the breakdown of food.

For individuals with conditions like pancreatic insufficiency, these supplements compensate for the lack of digestive enzymes and promote the proper breakdown of macronutrients.

In cases of malabsorption, such as in celiac disease, digestive enzyme supplements may alleviate symptoms by assisting with the breakdown of problematic components like gluten, enhancing nutrient absorption(6).

Support for Digestive Health

Individuals experiencing bloating, gas, and indigestion may find relief with digestive enzyme supplements. By promoting efficient digestion, these products could reduce the likelihood of discomfort.

Through aiding in the breakdown of nutrients, digestive enzyme supplements can also reduce the workload on the digestive system. This offers a reprieve to organs like the stomach, pancreas, and small intestine.

Top Digestive Enzymes and Probiotics

Choosing the right digestive enzymes and probiotics is essential for those seeking to enhance their intestinal health. A plethora of products is available, each offering unique benefits.

Let’s explore some top products to help you make informed decisions in your quest for optimal gut well-being.

Best Digestive Enzymes

  1. Pure Encapsulations Digestive Enzymes Ultra is a high-strength mixture of vegetarian enzymes that support enhanced protein, carbohydrate, fat, fiber, and dairy digestion. The compounds included in this formula promote optimal activity across a wide pH range.
  1. NutriDyn Digestive Complete is a comprehensive enzyme complex that supports healthy digestion and the absorption of nutrients. The product also contains numerous complementary ingredients that further support optimal intestinal function.
  1. NutriDyn Digestive Vegetarian blends 11 non-animal derived enzymes to enhance digestion and support the proper absorption of carbohydrates, proteins, fats, lactose, sucrose, cellulose and maltose. 

Best Digestive Enzymes with Probiotics

Simply Nutrients Simply Fruits and Greens is a great tasting digestive enzyme and probiotic combination. The powdered supplement also packs natural fruit and vegetable extracts to support healthy gastrointestinal function and prove energy and vitality.

When Should I Take Digestive Enzymes?

The optimal timing for taking digestive enzymes can significantly impact their effectiveness in supporting digestion. 

Generally, healthcare providers recommend taking these supplements around 15–30 minutes before meals. This ensures that the enzymes are present in the digestive tract as soon as you ingest food, facilitating the efficient breakdown of nutrients.

If you have multiple meals or snacks throughout the day, consider taking your supplement at each occasion to maintain a consistent enzyme presence.

Some individuals find that they achieve the best results when taking their digestive enzymes during or after a meal. Experiment with timing to determine what works best for your needs, but always follow the recommended dosage on the product label.

Foods That Naturally Contain Digestive Enzymes

Incorporating foods rich in natural digestive enzymes into your diet can provide valuable support for a healthy digestive system. Here are some foods that are naturally abundant in these crucial compounds:

  • Pineapple
  • Papaya
  • Kiwi
  • Mango
  • Avocado
  • Banana
  • Sauerkraut
  • Kimchi
  • Honey
  • Ginger

Important note: Cooking can sometimes destroy the enzymes found in food. Therefore, incorporating a variety of fresh, raw, or minimally processed fruits and veggies into your diet can maximize the benefits of natural digestive enzymes.

Transform Your Digestive Health

Transforming your digestive health is a commitment to nurturing your body from the inside out. The benefits of digestive enzymes with probiotics can revolutionize the way you process and absorb nutrients.

As you incorporate these powerful allies into your routine, remember that transformation is a gradual process. Be patient with your body as it adapts, and revel in the small victories—the reduced bloating, increased energy, and newfound digestive ease.

Contact us for more information on how to cultivate a lifestyle that achieves lasting digestive wellness.

Frequently Asked Questions

Still looking for some answers about your journey to digestive health? Let’s delve into some frequently asked questions about digestive enzymes to help you understand them even more.

What Happens to Your Body When You Start Taking Digestive Enzymes?

When you start taking digestive enzymes, the efficiency of the breakdown of complex macronutrients into more easily usable forms is enhanced, leading to improved nutrient absorption. 

This in turn can alleviate common digestive discomforts such as bloating and gas, and could lead to increased energy levels.

Is There a Downside to Taking Digestive Enzymes?

While digestive enzymes are generally safe and beneficial, over-reliance on the supplements may mask underlying issues and could interact with certain medications. Digestive enzymes also shouldn’t replace a healthy diet.

Ensure to consult with your healthcare professional before incorporating them into your regimen to ensure they align with your personal health needs.

Who Shouldn’t Take Digestive Enzymes?

Individuals who have known allergies to specific enzymes, pancreatitis, gastric ulcers, or bleeding disorders shouldn’t take digestive enzymes without consulting a doctor. 

In addition, pregnant or breastfeeding women, children, and anyone who has recently undergone gastrointestinal surgery should avoid taking these supplements.

Is It Good to Take Probiotics With Digestive Enzymes?

Yes, it is often beneficial to take probiotics with digestive enzymes. They serve complementary roles in supporting gut health, and their combined use can provide comprehensive benefits.

How Do I Know If I Need Digestive Enzymes or Probiotics?

If you frequently experience bloating, gas, indigestion, or discomfort after meals, it may indicate a need for digestive enzymes to assist in breaking down food more efficiently.

Issues like irregular bowel movements, diarrhea, or signs of an imbalance gut microbiome could suggest a potential benefit from probiotics.    









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Medically reviewed by Dr. Jamy Antoine, D.C. — by Chris Bowman — On December 21, 2023


Chris Bowman

Chris Bowman is the CEO and Co-Founder of and has over 15 years of experience in nutritional sciences and wellness. Simply Nutrients is a part of Dr. Jamy Antoine's Select Health Practice in Edina, Minnesota. Chris is passionate about helping people live healthier lives by using the best practices of nature, nutrition, and medicine.